Drug interactions
Epinephrine + Lisdexamfetamine
Severity: Major
Epinephrine and Lisdexamfetamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine and amphetamine both stimulate the sympathetic system, so together they can cause greater increases in blood pressure and heart rate and may precipitate arrhythmias. The effect is more pronounced with systemic epinephrine than with small local anesthetic doses.
What this interaction means in plain words
Epinephrine and Lisdexamfetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Epinephrine belongs to Endocrine; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Additive sympathomimetic effects: direct adrenergic agonism plus amphetamine-induced catecholamine release.
What to do
Monitor blood pressure, heart rate and ECG when systemic epinephrine is needed. Use the lowest effective epinephrine dose, but do not withhold it in anaphylaxis.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Lisdexamfetamine?
MediHelp rates the interaction as major. Epinephrine and Lisdexamfetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Epinephrine and amphetamine both stimulate the sympathetic system, so together they can cause greater increases in blood pressure and heart rate and may precipitate arrhythmias. The effect is more pronounced with systemic epinephrine than with small local anesthetic doses.
How serious is the interaction between Epinephrine and Lisdexamfetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG when systemic epinephrine is needed. Use the lowest effective epinephrine dose, but do not withhold it in anaphylaxis.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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