Drug interactions
Epinephrine + Posaconazole
Severity: Moderate
Epinephrine and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine can contribute to QT prolongation and arrhythmias, so combining it with posaconazole may add to repolarisation risk. The concern is mainly with systemic or repeated high-dose use, and is less relevant for emergency anaphylaxis dosing or local anaesthetic use.
What this interaction means in plain words
Epinephrine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Posaconazole belongs to Anti Fungals.
Why it happens
Additive effects on cardiac repolarisation; epinephrine's QT effect is largely adrenergic and indirect.
What to do
Use epinephrine when clinically indicated, with continuous ECG monitoring in critically ill patients. Correct hypokalaemia and hypomagnesaemia, which increase arrhythmia risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Epinephrine and Posaconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Posaconazole?
MediHelp rates the interaction as moderate. Epinephrine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine can contribute to QT prolongation and arrhythmias, so combining it with posaconazole may add to repolarisation risk. The concern is mainly with systemic or repeated high-dose use, and is less relevant for emergency anaphylaxis dosing or local anaesthetic use.
How serious is the interaction between Epinephrine and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use epinephrine when clinically indicated, with continuous ECG monitoring in critically ill patients. Correct hypokalaemia and hypomagnesaemia, which increase arrhythmia risk.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
