Drug interactions
Epinephrine + Prochlorperazine
Severity: Moderate
Epinephrine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine can provoke tachyarrhythmias, and phenothiazines may prolong the QT interval. Phenothiazines also block alpha-adrenergic receptors, which can blunt the pressor effect of epinephrine and cause hypotension with tachycardia.
What this interaction means in plain words
Epinephrine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Prochlorperazine belongs to Central Nervous System.
Why it happens
Alpha-adrenergic blockade by prochlorperazine altering the epinephrine response, plus additive arrhythmogenic effects.
What to do
Use epinephrine as clinically required, for example in anaphylaxis, while monitoring blood pressure and ECG. Avoid epinephrine to treat phenothiazine-induced hypotension and use norepinephrine or phenylephrine instead.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Prochlorperazine?
MediHelp rates the interaction as moderate. Epinephrine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine can provoke tachyarrhythmias, and phenothiazines may prolong the QT interval. Phenothiazines also block alpha-adrenergic receptors, which can blunt the pressor effect of epinephrine and cause hypotension with tachycardia.
How serious is the interaction between Epinephrine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use epinephrine as clinically required, for example in anaphylaxis, while monitoring blood pressure and ECG. Avoid epinephrine to treat phenothiazine-induced hypotension and use norepinephrine or phenylephrine instead.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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