Drug interactions
Epinephrine racemic + Lisdexamfetamine
Severity: Moderate
Epinephrine racemic and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Racemic epinephrine is an adrenergic agonist usually given by inhalation, and lisdexamfetamine increases catecholamine activity. Together they may raise heart rate and blood pressure and provoke arrhythmias. The effect is usually modest with inhaled dosing.
What this interaction means in plain words
Epinephrine racemic and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic stimulation from direct receptor agonism and amphetamine-induced catecholamine release.
What to do
Monitor heart rate and blood pressure, particularly in patients with cardiovascular disease. Use the lowest effective epinephrine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Epinephrine racemic with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Epinephrine racemic and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Racemic epinephrine is an adrenergic agonist usually given by inhalation, and lisdexamfetamine increases catecholamine activity. Together they may raise heart rate and blood pressure and provoke arrhythmias. The effect is usually modest with inhaled dosing.
How serious is the interaction between Epinephrine racemic and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, particularly in patients with cardiovascular disease. Use the lowest effective epinephrine dose.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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