Drug interactions
Epinephrine racemic + Posaconazole
Severity: Minor
Epinephrine racemic and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine may contribute to QT prolongation and arrhythmia, particularly at high or systemic exposure. With posaconazole this may add to arrhythmia risk, although inhaled racemic epinephrine has limited systemic exposure.
What this interaction means in plain words
Epinephrine racemic and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive QT effects and catecholamine-related proarrhythmic effects.
What to do
No routine change is needed for typical inhaled use. In patients with QT risk factors, monitor ECG and keep electrolytes in range.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Epinephrine racemic with Posaconazole?
MediHelp rates the interaction as minor. Epinephrine racemic and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Epinephrine may contribute to QT prolongation and arrhythmia, particularly at high or systemic exposure. With posaconazole this may add to arrhythmia risk, although inhaled racemic epinephrine has limited systemic exposure.
How serious is the interaction between Epinephrine racemic and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed for typical inhaled use. In patients with QT risk factors, monitor ECG and keep electrolytes in range.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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