Drug interactions
Eplerenone + Etodolac
Severity: Moderate
Eplerenone and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the antihypertensive effect of eplerenone and, in combination, raise the risk of hyperkalemia and renal impairment. Risk is higher in the elderly, volume-depleted or those with CKD.
What this interaction means in plain words
Eplerenone and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eplerenone belongs to Cardiovascular; Etodolac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes sodium retention and reduced renal perfusion and potassium excretion.
What to do
Monitor blood pressure, serum potassium and creatinine when starting or changing the NSAID. Use the lowest NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Eplerenone with Etodolac?
MediHelp rates the interaction as moderate. Eplerenone and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the antihypertensive effect of eplerenone and, in combination, raise the risk of hyperkalemia and renal impairment. Risk is higher in the elderly, volume-depleted or those with CKD.
How serious is the interaction between Eplerenone and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and creatinine when starting or changing the NSAID. Use the lowest NSAID dose for the shortest time.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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