Drug interactions
Eplerenone + Sulphasalazine
Severity: Minor
Eplerenone and Sulphasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine is a sulfonamide prodrug of 5-aminosalicylic acid and is not an NSAID in the sense of potent prostaglandin inhibition. A meaningful reduction in eplerenone effect is not expected.
What this interaction means in plain words
Eplerenone and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eplerenone belongs to Cardiovascular; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Theoretical prostaglandin-mediated antagonism of diuretic effect; not established for sulfasalazine.
What to do
No specific action. Monitor blood pressure and renal function as routine for eplerenone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Asciminib + Sulphasalazine Moderate
Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Eplerenone with Sulphasalazine?
MediHelp rates the interaction as minor. Eplerenone and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine is a sulfonamide prodrug of 5-aminosalicylic acid and is not an NSAID in the sense of potent prostaglandin inhibition. A meaningful reduction in eplerenone effect is not expected.
How serious is the interaction between Eplerenone and Sulphasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action. Monitor blood pressure and renal function as routine for eplerenone.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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