Drug interactions
Eplerenone + Tolfenamic acid
Severity: Moderate
Eplerenone and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the blood pressure lowering effect of eplerenone and reduce renal function. Together they also raise the risk of hyperkalemia and acute kidney injury.
What this interaction means in plain words
Eplerenone and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eplerenone belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAIDs inhibit renal prostaglandin synthesis, causing sodium retention and reduced renal perfusion and potassium excretion.
What to do
Monitor blood pressure, serum creatinine and potassium after starting the NSAID, and use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Eplerenone with Tolfenamic acid?
MediHelp rates the interaction as moderate. Eplerenone and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the blood pressure lowering effect of eplerenone and reduce renal function. Together they also raise the risk of hyperkalemia and acute kidney injury.
How serious is the interaction between Eplerenone and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting the NSAID, and use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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