Drug interactions
Eplerenone + Verapamil
Severity: Moderate
Eplerenone and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil is a moderate CYP3A4 inhibitor and raises eplerenone exposure. Higher levels increase the risk of hyperkalemia and hypotension.
What this interaction means in plain words
Eplerenone and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eplerenone belongs to Cardiovascular; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4-mediated metabolism of eplerenone, reducing its clearance.
What to do
Monitor potassium and blood pressure. Limit eplerenone to a reduced maximum daily dose per the product labeling for moderate CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Eplerenone with Verapamil?
MediHelp rates the interaction as moderate. Eplerenone and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil is a moderate CYP3A4 inhibitor and raises eplerenone exposure. Higher levels increase the risk of hyperkalemia and hypotension.
How serious is the interaction between Eplerenone and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and blood pressure. Limit eplerenone to a reduced maximum daily dose per the product labeling for moderate CYP3A4 inhibitors.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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