Drug interactions
Epoprostenol + Metolazone
Severity: Moderate
Epoprostenol and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol is a potent vasodilator and metolazone lowers blood pressure through volume depletion, so the combination may produce additive hypotension. This is relevant in pulmonary hypertension patients on diuretics.
What this interaction means in plain words
Epoprostenol and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epoprostenol belongs to Genitourinary; Metolazone belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering through vasodilation and diuretic-induced volume reduction.
What to do
Monitor blood pressure and volume status, especially when starting or adjusting either drug. Reduce doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Epoprostenol with Metolazone?
MediHelp rates the interaction as moderate. Epoprostenol and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol is a potent vasodilator and metolazone lowers blood pressure through volume depletion, so the combination may produce additive hypotension. This is relevant in pulmonary hypertension patients on diuretics.
How serious is the interaction between Epoprostenol and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and volume status, especially when starting or adjusting either drug. Reduce doses if symptomatic hypotension occurs.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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