Drug interactions
Eprosartan + Hydrochlorothiazide
Severity: Minor
Eprosartan and Hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eprosartan tends to raise potassium while hydrochlorothiazide lowers it, so the two partly offset each other. The combination is widely used and beneficial for blood pressure, but the net potassium effect and the risk of volume depletion or reduced renal function vary between patients.
What this interaction means in plain words
Eprosartan and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eprosartan belongs to Cardiovascular; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Angiotensin receptor blockade reduces aldosterone-mediated potassium excretion, opposing the potassium loss caused by thiazide diuresis.
What to do
Check serum potassium, creatinine and blood pressure after starting or changing doses. No routine adjustment is needed if values are stable.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Eprosartan with Hydrochlorothiazide?
MediHelp rates the interaction as minor. Eprosartan and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eprosartan tends to raise potassium while hydrochlorothiazide lowers it, so the two partly offset each other. The combination is widely used and beneficial for blood pressure, but the net potassium effect and the risk of volume depletion or reduced renal function vary between patients.
How serious is the interaction between Eprosartan and Hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium, creatinine and blood pressure after starting or changing doses. No routine adjustment is needed if values are stable.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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