Drug interactions
Eprosartan-hydrochlorothiazide + Glipizide
Severity: Minor
Eprosartan-hydrochlorothiazide and Glipizide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and blunt the effect of glipizide. The impact is generally small at low thiazide doses but may matter in patients whose diabetes is poorly controlled.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Glipizide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Glipizide belongs to Endocrine.
Why it happens
Thiazide-related hypokalemia and impaired insulin release and sensitivity antagonize sulfonylurea glucose lowering.
What to do
Monitor blood glucose and HbA1c when the combination is started or the thiazide dose changes. Increase the glipizide dose if needed and keep potassium in the normal range.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eprosartan-hydrochlorothiazide and Glipizide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Glipizide
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Glipizide?
MediHelp rates the interaction as minor. Eprosartan-hydrochlorothiazide and Glipizide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide can raise blood glucose and blunt the effect of glipizide. The impact is generally small at low thiazide doses but may matter in patients whose diabetes is poorly controlled.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Glipizide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when the combination is started or the thiazide dose changes. Increase the glipizide dose if needed and keep potassium in the normal range.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
