Drug interactions
Eprosartan-hydrochlorothiazide + Hydrochlorothiazide
Severity: Moderate
Eprosartan-hydrochlorothiazide and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination product already contains hydrochlorothiazide, so adding a separate hydrochlorothiazide duplicates therapy. This increases the risk of hypokalemia, hyponatremia, hypotension, volume depletion and metabolic effects.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Therapeutic duplication of the thiazide component gives an exaggerated diuretic and electrolyte effect.
What to do
Avoid concurrent use of separate hydrochlorothiazide with the fixed-dose combination and adjust the regimen to a single thiazide source. If a higher thiazide dose is needed, change doses of the combination instead and monitor electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eprosartan-hydrochlorothiazide and Hydrochlorothiazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination product already contains hydrochlorothiazide, so adding a separate hydrochlorothiazide duplicates therapy. This increases the risk of hypokalemia, hyponatremia, hypotension, volume depletion and metabolic effects.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of separate hydrochlorothiazide with the fixed-dose combination and adjust the regimen to a single thiazide source. If a higher thiazide dose is needed, change doses of the combination instead and monitor electrolytes.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
