Drug interactions
Eprosartan-hydrochlorothiazide + Midodrine
Severity: Moderate
Eprosartan-hydrochlorothiazide and Midodrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine raises blood pressure, directly opposing the antihypertensive effect of this combination product. The pharmacokinetic competition for renal secretion is of little significance compared with this opposing effect.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Midodrine belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism, as midodrine's alpha-1 agonist vasoconstriction counters the blood-pressure lowering of eprosartan and hydrochlorothiazide.
What to do
Monitor supine and standing blood pressure and reassess the need for each drug. Adjust doses to avoid supine hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Midodrine?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midodrine raises blood pressure, directly opposing the antihypertensive effect of this combination product. The pharmacokinetic competition for renal secretion is of little significance compared with this opposing effect.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Midodrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure and reassess the need for each drug. Adjust doses to avoid supine hypertension.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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