Drug interactions
Eptifibatide + Vortioxetine
Severity: Moderate
Eptifibatide and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine can impair platelet serotonin uptake and modestly raise bleeding risk. With eptifibatide, the combined effect on hemostasis may increase bleeding.
What this interaction means in plain words
Eptifibatide and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eptifibatide belongs to Cardiovascular; Vortioxetine belongs to Central Nervous System.
Why it happens
Reduced platelet serotonin uptake adds to GP IIb/IIIa receptor inhibition.
What to do
Monitor for bleeding and hemoglobin during eptifibatide therapy. Reassess the antidepressant if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eptifibatide
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Eptifibatide with Vortioxetine?
MediHelp rates the interaction as moderate. Eptifibatide and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine can impair platelet serotonin uptake and modestly raise bleeding risk. With eptifibatide, the combined effect on hemostasis may increase bleeding.
How serious is the interaction between Eptifibatide and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and hemoglobin during eptifibatide therapy. Reassess the antidepressant if bleeding occurs.
What other medicines interact with Eptifibatide?
MediHelp also lists interactions of Eptifibatide with, for example, Abrocitinib, Acalabrutinib, Acetylsalicylic acid. The full list is on the Eptifibatide page.
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