Drug interactions
Erdafitinib + Estradiol
Severity: Minor
Erdafitinib and Estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits P-glycoprotein, and estradiol is a P-gp substrate, so estradiol exposure may rise modestly. The clinical consequence is likely small, with estrogen-related adverse effects the main concern.
What this interaction means in plain words
Erdafitinib and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erdafitinib belongs to Oncology; Estradiol belongs to Endocrine.
Why it happens
Erdafitinib inhibits intestinal P-gp efflux of estradiol, which may increase its absorption.
What to do
No routine change is required; monitor for estrogen excess symptoms such as breast tenderness or fluid retention. Dose-reduce estradiol if effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Estradiol?
MediHelp rates the interaction as minor. Erdafitinib and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erdafitinib inhibits P-glycoprotein, and estradiol is a P-gp substrate, so estradiol exposure may rise modestly. The clinical consequence is likely small, with estrogen-related adverse effects the main concern.
How serious is the interaction between Erdafitinib and Estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is required; monitor for estrogen excess symptoms such as breast tenderness or fluid retention. Dose-reduce estradiol if effects appear.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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