Drug interactions
Erdafitinib + Gemfibrozil
Severity: Moderate
Erdafitinib and Gemfibrozil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib is cleared mainly by CYP2C9 and CYP3A4, and gemfibrozil inhibits CYP2C9 along with CYP2C8. Erdafitinib exposure may increase, raising the risk of hyperphosphatemia, ocular toxicity and stomatitis.
What this interaction means in plain words
Erdafitinib and Gemfibrozil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Gemfibrozil belongs to Cardiovascular.
Why it happens
Gemfibrozil inhibits CYP2C9-mediated metabolism of erdafitinib.
What to do
Prefer a different lipid-lowering agent. If coadministration is needed, monitor closely for adverse reactions and reduce the erdafitinib dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Gemfibrozil?
MediHelp rates the interaction as moderate. Erdafitinib and Gemfibrozil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib is cleared mainly by CYP2C9 and CYP3A4, and gemfibrozil inhibits CYP2C9 along with CYP2C8. Erdafitinib exposure may increase, raising the risk of hyperphosphatemia, ocular toxicity and stomatitis.
How serious is the interaction between Erdafitinib and Gemfibrozil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a different lipid-lowering agent. If coadministration is needed, monitor closely for adverse reactions and reduce the erdafitinib dose as needed.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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