Drug interactions
Erdafitinib + Ranolazine
Severity: Moderate
Erdafitinib and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib may inhibit P-gp and increase ranolazine exposure, with greater risk of dose-related adverse effects including QT prolongation. The magnitude is uncertain.
What this interaction means in plain words
Erdafitinib and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Ranolazine belongs to Cardiovascular.
Why it happens
P-gp inhibition by erdafitinib reduces ranolazine efflux.
What to do
Monitor for dizziness, nausea and QTc changes. Reduce the ranolazine dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Ranolazine?
MediHelp rates the interaction as moderate. Erdafitinib and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib may inhibit P-gp and increase ranolazine exposure, with greater risk of dose-related adverse effects including QT prolongation. The magnitude is uncertain.
How serious is the interaction between Erdafitinib and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, nausea and QTc changes. Reduce the ranolazine dose if adverse effects occur.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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