Drug interactions
Erdafitinib + Sofosbuvir
Severity: Minor
Erdafitinib and Sofosbuvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits P-gp and may modestly raise sofosbuvir exposure. Because sofosbuvir has a wide margin of safety, clinical impact is probably small.
What this interaction means in plain words
Erdafitinib and Sofosbuvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erdafitinib belongs to Oncology; Sofosbuvir belongs to Anti Virals.
Why it happens
Erdafitinib inhibits intestinal P-gp efflux of sofosbuvir.
What to do
No dose adjustment is needed; monitor for sofosbuvir adverse effects such as fatigue and headache.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Sofosbuvir?
MediHelp rates the interaction as minor. Erdafitinib and Sofosbuvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erdafitinib inhibits P-gp and may modestly raise sofosbuvir exposure. Because sofosbuvir has a wide margin of safety, clinical impact is probably small.
How serious is the interaction between Erdafitinib and Sofosbuvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for sofosbuvir adverse effects such as fatigue and headache.
What other medicines interact with Sofosbuvir?
MediHelp also lists interactions of Sofosbuvir with, for example, Amiodarone, Apalutamide, Carbamazepine. The full list is on the Sofosbuvir page.
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