Drug interactions
Erdafitinib + Temsirolimus
Severity: Moderate
Erdafitinib and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits P-glycoprotein and may raise exposure to temsirolimus, which is a P-gp substrate. Higher levels could increase toxicities such as mucositis, cytopenias, hyperglycemia and pneumonitis.
What this interaction means in plain words
Erdafitinib and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Temsirolimus belongs to Oncology.
Why it happens
Erdafitinib inhibits P-gp efflux, reducing the elimination of temsirolimus and its active metabolite sirolimus.
What to do
Prefer an alternative where possible; if used together, separate temsirolimus from erdafitinib by at least 6 hours and monitor for temsirolimus toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Temsirolimus?
MediHelp rates the interaction as moderate. Erdafitinib and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib inhibits P-glycoprotein and may raise exposure to temsirolimus, which is a P-gp substrate. Higher levels could increase toxicities such as mucositis, cytopenias, hyperglycemia and pneumonitis.
How serious is the interaction between Erdafitinib and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative where possible; if used together, separate temsirolimus from erdafitinib by at least 6 hours and monitor for temsirolimus toxicity.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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