Drug interactions
Ergocalciferol + Indapamide
Severity: Moderate
Ergocalciferol and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide, a thiazide-like diuretic, reduces urinary calcium excretion and may cause hypercalcemia with vitamin D. Risk is greater with high doses and in renal impairment.
What this interaction means in plain words
Ergocalciferol and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergocalciferol belongs to Musculoskeletal; Indapamide belongs to Cardiovascular.
Why it happens
Indapamide increases renal calcium reabsorption, adding to vitamin D-driven calcium absorption.
What to do
Monitor serum calcium periodically. Lower the vitamin D dose if calcium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergocalciferol
- Aluminum hydroxide + Ergocalciferol Moderate
- Calcium acetate + Ergocalciferol Moderate
- Calcium carbonate + Ergocalciferol Moderate
- Calcium chloride + Ergocalciferol Moderate
- Calcium citrate + Ergocalciferol Moderate
- Calcium gluconate + Ergocalciferol Moderate
Other interactions of Indapamide
Frequently asked questions
Can I take Ergocalciferol with Indapamide?
MediHelp rates the interaction as moderate. Ergocalciferol and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide, a thiazide-like diuretic, reduces urinary calcium excretion and may cause hypercalcemia with vitamin D. Risk is greater with high doses and in renal impairment.
How serious is the interaction between Ergocalciferol and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically. Lower the vitamin D dose if calcium rises.
What other medicines interact with Ergocalciferol?
MediHelp also lists interactions of Ergocalciferol with, for example, Aluminum hydroxide, Calcium acetate, Calcium carbonate. The full list is on the Ergocalciferol page.
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