Drug interactions
Ergotamine + Glycerol phenylbutyrate
Severity: Minor
Ergotamine and Glycerol phenylbutyrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glycerol phenylbutyrate is a weak CYP3A4 inducer and may lower ergotamine concentrations. The clinical consequence is probably reduced headache relief rather than toxicity.
What this interaction means in plain words
Ergotamine and Glycerol phenylbutyrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ergotamine belongs to Central Nervous System; Glycerol phenylbutyrate belongs to Miscellaneous.
Why it happens
Weak induction of CYP3A4 may increase ergotamine metabolism.
What to do
Monitor for reduced antimigraine efficacy. Avoid escalating the ergotamine dose beyond labeled limits and consider another therapy if it is ineffective.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Glycerol phenylbutyrate
- Dexamethasone + Glycerol phenylbutyrate Major
- Glycerol phenylbutyrate + Valproic acid Major
- Cyclosporin + Glycerol phenylbutyrate Moderate
- Dexamethasone-neomycin-polymyxin + Glycerol phenylbutyrate Moderate
- Dexamethasone-tobramycin + Glycerol phenylbutyrate Moderate
- Fludrocortisone + Glycerol phenylbutyrate Moderate
Frequently asked questions
Can I take Ergotamine with Glycerol phenylbutyrate?
MediHelp rates the interaction as minor. Ergotamine and Glycerol phenylbutyrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glycerol phenylbutyrate is a weak CYP3A4 inducer and may lower ergotamine concentrations. The clinical consequence is probably reduced headache relief rather than toxicity.
How serious is the interaction between Ergotamine and Glycerol phenylbutyrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antimigraine efficacy. Avoid escalating the ergotamine dose beyond labeled limits and consider another therapy if it is ineffective.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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