Drug interactions
Ergotamine + Imipramine
Severity: Moderate
Ergotamine and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can enhance serotonergic activity, and ergotamine also causes vasoconstriction. Serotonin toxicity is possible, though documentation is limited and mainly theoretical.
What this interaction means in plain words
Ergotamine and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergotamine belongs to Central Nervous System; Imipramine belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from imipramine reuptake inhibition and ergotamine 5-HT receptor agonism.
What to do
Monitor for serotonin syndrome and for ischemic symptoms such as cold or painful extremities; limit ergotamine dosing and frequency.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Imipramine?
MediHelp rates the interaction as moderate. Ergotamine and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can enhance serotonergic activity, and ergotamine also causes vasoconstriction. Serotonin toxicity is possible, though documentation is limited and mainly theoretical.
How serious is the interaction between Ergotamine and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome and for ischemic symptoms such as cold or painful extremities; limit ergotamine dosing and frequency.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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