Drug interactions
Ergotamine + Istradefylline
Severity: Moderate
Ergotamine and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at 40 mg daily has increased exposure to CYP3A4 substrates, so it may raise ergotamine levels. Higher ergotamine exposure raises the risk of vasospasm.
What this interaction means in plain words
Ergotamine and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergotamine belongs to Central Nervous System; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline inhibits CYP3A4 at higher doses, reducing ergotamine metabolism.
What to do
Monitor for ergotism, especially if the istradefylline dose is 40 mg daily. Reduce the ergotamine dose or choose an alternative therapy if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Ergotamine with Istradefylline?
MediHelp rates the interaction as moderate. Ergotamine and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Istradefylline at 40 mg daily has increased exposure to CYP3A4 substrates, so it may raise ergotamine levels. Higher ergotamine exposure raises the risk of vasospasm.
How serious is the interaction between Ergotamine and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ergotism, especially if the istradefylline dose is 40 mg daily. Reduce the ergotamine dose or choose an alternative therapy if symptoms appear.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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