Drug interactions
Ergotamine + Larotrectinib
Severity: Moderate
Ergotamine and Larotrectinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate with weak inhibitory potential in vitro. Its effect on ergotamine is poorly characterized but could increase ergotamine exposure.
What this interaction means in plain words
Ergotamine and Larotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergotamine belongs to Central Nervous System; Larotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib may reduce ergotamine metabolism.
What to do
Monitor for ergotism including cold extremities and paresthesia. Consider a non-ergot alternative for migraine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Ergotamine with Larotrectinib?
MediHelp rates the interaction as moderate. Ergotamine and Larotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Larotrectinib is a CYP3A4 substrate with weak inhibitory potential in vitro. Its effect on ergotamine is poorly characterized but could increase ergotamine exposure.
How serious is the interaction between Ergotamine and Larotrectinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ergotism including cold extremities and paresthesia. Consider a non-ergot alternative for migraine.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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