Drug interactions
Ergotamine + Minocycline
Severity: Moderate
Ergotamine and Minocycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergotism with vasospasm and ischemia has been described with ergot alkaloids and some antibiotics, mainly macrolides, and is not well established for tetracyclines. The data supporting this specific pairing are very limited.
What this interaction means in plain words
Ergotamine and Minocycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergotamine belongs to Central Nervous System; Minocycline belongs to Anti Bacterial.
Why it happens
Mechanism is not established; possible effects on ergot metabolism are speculative.
What to do
Monitor for numbness, tingling, cold or painful extremities, and stop ergotamine if ischemic symptoms appear. Limit ergotamine dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ergotamine and Minocycline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Minocycline
- Acitretin + Minocycline Contraindicated
- Isotretinoin + Minocycline Contraindicated
- Cholera vaccine + Minocycline Major
- Methoxyflurane + Minocycline Major
- Minocycline + Palovarotene Major
- Minocycline + Pexidartinib Major
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Minocycline?
MediHelp rates the interaction as moderate. Ergotamine and Minocycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ergotism with vasospasm and ischemia has been described with ergot alkaloids and some antibiotics, mainly macrolides, and is not well established for tetracyclines. The data supporting this specific pairing are very limited.
How serious is the interaction between Ergotamine and Minocycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for numbness, tingling, cold or painful extremities, and stop ergotamine if ischemic symptoms appear. Limit ergotamine dosing.
What other medicines interact with Minocycline?
MediHelp also lists interactions of Minocycline with, for example, Acitretin, Isotretinoin, Cholera vaccine. The full list is on the Minocycline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
