Drug interactions
Ergotamine + Morphine
Severity: Minor
Ergotamine and Morphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been loosely linked to serotonergic effects, but a clinically significant serotonin syndrome with morphine and ergotamine is poorly documented. The main concern with ergotamine is vasoconstriction and its interactions with CYP3A4 inhibitors, not with morphine.
What this interaction means in plain words
Ergotamine and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ergotamine belongs to Central Nervous System; Morphine belongs to Musculoskeletal.
Why it happens
Possible weak additive serotonergic activity; not well established.
What to do
No specific action beyond awareness; counsel patients to report agitation, tremor, fever or sweating.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Morphine?
MediHelp rates the interaction as minor. Ergotamine and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs have been loosely linked to serotonergic effects, but a clinically significant serotonin syndrome with morphine and ergotamine is poorly documented. The main concern with ergotamine is vasoconstriction and its interactions with CYP3A4 inhibitors, not with morphine.
How serious is the interaction between Ergotamine and Morphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action beyond awareness; counsel patients to report agitation, tremor, fever or sweating.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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