Drug interactions
Ergotamine + Pimavanserin
Severity: Moderate
Ergotamine and Pimavanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergotamine has serotonergic activity and pimavanserin modulates serotonin receptors, so additive serotonergic effects are theoretically possible. Documented cases are lacking.
What this interaction means in plain words
Ergotamine and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergotamine belongs to Central Nervous System; Pimavanserin belongs to Central Nervous System.
Why it happens
Additive serotonergic pharmacodynamic activity; largely theoretical.
What to do
Monitor for signs of serotonin toxicity such as agitation, tremor, hyperthermia and clonus, and for ergotism symptoms with repeated ergotamine use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Frequently asked questions
Can I take Ergotamine with Pimavanserin?
MediHelp rates the interaction as moderate. Ergotamine and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ergotamine has serotonergic activity and pimavanserin modulates serotonin receptors, so additive serotonergic effects are theoretically possible. Documented cases are lacking.
How serious is the interaction between Ergotamine and Pimavanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity such as agitation, tremor, hyperthermia and clonus, and for ergotism symptoms with repeated ergotamine use.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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