Drug interactions
Ergotamine + Pirtobrutinib
Severity: Moderate
Ergotamine and Pirtobrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pirtobrutinib is a weak CYP3A4 inhibitor and may increase ergotamine exposure. Because ergotamine toxicity includes severe ischemia, even modest increases matter.
What this interaction means in plain words
Ergotamine and Pirtobrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergotamine belongs to Central Nervous System; Pirtobrutinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by pirtobrutinib reduces ergotamine metabolism.
What to do
Monitor for ergotism, including cold or numb extremities and nausea. Prefer a non-ergot migraine therapy if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Pirtobrutinib
Frequently asked questions
Can I take Ergotamine with Pirtobrutinib?
MediHelp rates the interaction as moderate. Ergotamine and Pirtobrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pirtobrutinib is a weak CYP3A4 inhibitor and may increase ergotamine exposure. Because ergotamine toxicity includes severe ischemia, even modest increases matter.
How serious is the interaction between Ergotamine and Pirtobrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ergotism, including cold or numb extremities and nausea. Prefer a non-ergot migraine therapy if possible.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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