Drug interactions
Ergotamine + Rasagiline
Severity: Moderate
Ergotamine and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have serotonergic activity, so combining them could theoretically increase the risk of serotonin toxicity. Ergotamine is also a vasoconstrictor, which could add to blood pressure effects. Clinical reports of significant harm are limited.
What this interaction means in plain words
Ergotamine and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergotamine belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Why it happens
Possible additive serotonergic and vasoconstrictive effects; MAO-B inhibition by rasagiline with serotonin receptor agonism by ergotamine.
What to do
Monitor for agitation, tremor, hyperthermia, diarrhea and blood pressure rises when starting or adjusting either drug. Consider a non-ergot migraine therapy if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Rasagiline?
MediHelp rates the interaction as moderate. Ergotamine and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have serotonergic activity, so combining them could theoretically increase the risk of serotonin toxicity. Ergotamine is also a vasoconstrictor, which could add to blood pressure effects. Clinical reports of significant harm are limited.
How serious is the interaction between Ergotamine and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia, diarrhea and blood pressure rises when starting or adjusting either drug. Consider a non-ergot migraine therapy if symptoms appear.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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