Drug interactions
Ergotamine + Sotorasib
Severity: Moderate
Ergotamine and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a modest CYP3A4 inducer and may reduce ergotamine concentrations, potentially lessening its antimigraine effect. The clinical significance is uncertain.
What this interaction means in plain words
Ergotamine and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergotamine belongs to Central Nervous System; Sotorasib belongs to Oncology.
Why it happens
Sotorasib induces CYP3A4, increasing ergotamine metabolism.
What to do
Monitor for reduced migraine control and consider a non-ergot alternative. Do not exceed labeled ergotamine doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Ergotamine with Sotorasib?
MediHelp rates the interaction as moderate. Ergotamine and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a modest CYP3A4 inducer and may reduce ergotamine concentrations, potentially lessening its antimigraine effect. The clinical significance is uncertain.
How serious is the interaction between Ergotamine and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced migraine control and consider a non-ergot alternative. Do not exceed labeled ergotamine doses.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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