Drug interactions
Eribulin + Erythromycin lactobionate
Severity: Major
Eribulin and Erythromycin lactobionate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin produces higher peak concentrations and carries a notable risk of QT prolongation and torsades de pointes. Eribulin adds to this effect, increasing the risk of ventricular arrhythmia.
What this interaction means in plain words
Eribulin and Erythromycin lactobionate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eribulin belongs to Oncology; Erythromycin lactobionate belongs to Anti Bacterial.
Why it happens
Additive pharmacodynamic QT prolongation; erythromycin blocks the IKr potassium current.
What to do
Use a non-QT-prolonging antibiotic when possible. If erythromycin is needed, check ECG and electrolytes and monitor during infusion.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eribulin
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Eribulin with Erythromycin lactobionate?
MediHelp rates the interaction as major. Eribulin and Erythromycin lactobionate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intravenous erythromycin produces higher peak concentrations and carries a notable risk of QT prolongation and torsades de pointes. Eribulin adds to this effect, increasing the risk of ventricular arrhythmia.
How serious is the interaction between Eribulin and Erythromycin lactobionate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-QT-prolonging antibiotic when possible. If erythromycin is needed, check ECG and electrolytes and monitor during infusion.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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