Drug interactions
Eribulin + Lopinavir
Severity: Major
Eribulin and Lopinavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir can prolong QT and PR intervals, and eribulin also lengthens QT. The combination may raise the risk of torsades de pointes, especially with electrolyte abnormalities or structural heart disease.
What this interaction means in plain words
Eribulin and Lopinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eribulin belongs to Oncology; Lopinavir belongs to Anti Virals.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Use an alternative antiretroviral if possible. If both are required, check baseline and periodic ECGs and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eribulin
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Eribulin with Lopinavir?
MediHelp rates the interaction as major. Eribulin and Lopinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lopinavir/ritonavir can prolong QT and PR intervals, and eribulin also lengthens QT. The combination may raise the risk of torsades de pointes, especially with electrolyte abnormalities or structural heart disease.
How serious is the interaction between Eribulin and Lopinavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antiretroviral if possible. If both are required, check baseline and periodic ECGs and correct potassium and magnesium.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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