Drug interactions
Eribulin + Mirtazapine
Severity: Moderate
Eribulin and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may add to the risk of torsades de pointes. Mirtazapine's effect is modest and mainly seen in overdose or with other risk factors, while eribulin carries a labeled QT warning.
What this interaction means in plain words
Eribulin and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eribulin belongs to Oncology; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation through effects on cardiac repolarization.
What to do
Obtain a baseline ECG and correct potassium and magnesium before starting. Repeat ECG monitoring during eribulin treatment, and consider an alternative antidepressant if the QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Mirtazapine?
MediHelp rates the interaction as moderate. Eribulin and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use may add to the risk of torsades de pointes. Mirtazapine's effect is modest and mainly seen in overdose or with other risk factors, while eribulin carries a labeled QT warning.
How serious is the interaction between Eribulin and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before starting. Repeat ECG monitoring during eribulin treatment, and consider an alternative antidepressant if the QTc becomes prolonged.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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