Drug interactions
Eribulin + Ondansetron
Severity: Moderate
Eribulin and Ondansetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and eribulin labeling advises caution with other QT-prolonging agents. The combination may raise the risk of arrhythmia, especially with electrolyte abnormalities.
What this interaction means in plain words
Eribulin and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eribulin belongs to Oncology; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation through effects on cardiac repolarization.
What to do
Correct hypokalemia and hypomagnesemia before treatment and monitor the ECG in patients with cardiac risk factors. Use a different antiemetic in congenital long QT syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Ondansetron?
MediHelp rates the interaction as moderate. Eribulin and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and eribulin labeling advises caution with other QT-prolonging agents. The combination may raise the risk of arrhythmia, especially with electrolyte abnormalities.
How serious is the interaction between Eribulin and Ondansetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct hypokalemia and hypomagnesemia before treatment and monitor the ECG in patients with cardiac risk factors. Use a different antiemetic in congenital long QT syndrome.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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