Drug interactions
Eribulin + Panobinostat
Severity: Major
Eribulin and Panobinostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat prolongs the QT interval and its labeling advises against combining it with other QT-prolonging drugs. Eribulin may add to this effect and raise the risk of torsades de pointes.
What this interaction means in plain words
Eribulin and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eribulin belongs to Oncology; Panobinostat belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid the combination. If it cannot be avoided, obtain ECG and electrolytes at baseline and regularly, and interrupt therapy for significant QTc prolongation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eribulin
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Eribulin with Panobinostat?
MediHelp rates the interaction as major. Eribulin and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Panobinostat prolongs the QT interval and its labeling advises against combining it with other QT-prolonging drugs. Eribulin may add to this effect and raise the risk of torsades de pointes.
How serious is the interaction between Eribulin and Panobinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If it cannot be avoided, obtain ECG and electrolytes at baseline and regularly, and interrupt therapy for significant QTc prolongation.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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