Drug interactions
Eribulin + Risperidone
Severity: Major
Eribulin and Risperidone: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval, and risperidone has a similar effect, so combined use may increase the risk of torsades de pointes. Risk is greater with electrolyte abnormalities or bradycardia.
What this interaction means in plain words
Eribulin and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eribulin belongs to Oncology; Risperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation through delayed ventricular repolarization.
What to do
Monitor ECG and electrolytes, correcting hypokalemia and hypomagnesemia before and during treatment. Consider an alternative to risperidone if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Okedi 100mg powder and solvent for prolonged-release suspension for injection pre-filled syringes - SmPC sections 4.3/4.5 (class statement: medicinal products known to prolong the QT interval; "Caution is advised when prescribing OKEDI with medicinal products known to prolong the QT interval") — electronic medicines compendium (UK SmPC)
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Risperidone?
MediHelp rates the interaction as major. Eribulin and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eribulin can prolong the QT interval, and risperidone has a similar effect, so combined use may increase the risk of torsades de pointes. Risk is greater with electrolyte abnormalities or bradycardia.
How serious is the interaction between Eribulin and Risperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, correcting hypokalemia and hypomagnesemia before and during treatment. Consider an alternative to risperidone if QTc becomes markedly prolonged.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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