Drug interactions
Eribulin + Sevoflurane
Severity: Moderate
Eribulin and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval and sevoflurane may add to this effect. The combination could increase the risk of ventricular arrhythmia, especially with electrolyte abnormalities.
What this interaction means in plain words
Eribulin and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eribulin belongs to Oncology; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Review the baseline ECG and correct potassium and magnesium before surgery. Monitor the ECG during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Sevoflurane?
MediHelp rates the interaction as moderate. Eribulin and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eribulin can prolong the QT interval and sevoflurane may add to this effect. The combination could increase the risk of ventricular arrhythmia, especially with electrolyte abnormalities.
How serious is the interaction between Eribulin and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the baseline ECG and correct potassium and magnesium before surgery. Monitor the ECG during anesthesia.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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