Drug interactions
Eribulin + Trazodone
Severity: Moderate
Eribulin and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval, and trazodone may add to this. Risk is greater with electrolyte disturbances or cardiac disease.
What this interaction means in plain words
Eribulin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eribulin belongs to Oncology; Trazodone belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Perform ECG monitoring and correct hypokalemia and hypomagnesemia before and during eribulin treatment. Consider an alternative to trazodone if QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Trazodone?
MediHelp rates the interaction as moderate. Eribulin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eribulin can prolong the QT interval, and trazodone may add to this. Risk is greater with electrolyte disturbances or cardiac disease.
How serious is the interaction between Eribulin and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform ECG monitoring and correct hypokalemia and hypomagnesemia before and during eribulin treatment. Consider an alternative to trazodone if QTc lengthens.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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