Drug interactions
Eribulin + Trimipramine
Severity: Moderate
Eribulin and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval, and trimipramine may also do so, particularly at high doses or with other risk factors. Combined use may increase the risk of ventricular arrhythmias including torsades de pointes.
What this interaction means in plain words
Eribulin and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eribulin belongs to Oncology; Trimipramine belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Perform an ECG before starting and periodically during therapy, and correct hypokalemia and hypomagnesemia. Consider an alternative antidepressant in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Trimipramine?
MediHelp rates the interaction as moderate. Eribulin and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eribulin can prolong the QT interval, and trimipramine may also do so, particularly at high doses or with other risk factors. Combined use may increase the risk of ventricular arrhythmias including torsades de pointes.
How serious is the interaction between Eribulin and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform an ECG before starting and periodically during therapy, and correct hypokalemia and hypomagnesemia. Consider an alternative antidepressant in patients with other QT risk factors.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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