Drug interactions
Erlotinib + Fluconazole
Severity: Moderate
Erlotinib and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erlotinib is metabolized mainly by CYP3A4, so fluconazole may raise its concentrations. This can increase rash, diarrhea and other dose-related toxicities.
What this interaction means in plain words
Erlotinib and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erlotinib belongs to Oncology; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibits CYP3A4 (and CYP1A2 to a lesser degree), reducing erlotinib clearance.
What to do
Monitor for diarrhea, rash and hepatic toxicity. Reduce the erlotinib dose stepwise if severe reactions occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Frequently asked questions
Can I take Erlotinib with Fluconazole?
MediHelp rates the interaction as moderate. Erlotinib and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erlotinib is metabolized mainly by CYP3A4, so fluconazole may raise its concentrations. This can increase rash, diarrhea and other dose-related toxicities.
How serious is the interaction between Erlotinib and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea, rash and hepatic toxicity. Reduce the erlotinib dose stepwise if severe reactions occur.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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