Drug interactions
Erlotinib + Stiripentol
Severity: Moderate
Erlotinib and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol can both inhibit and induce CYP3A4, so erlotinib exposure may rise or fall unpredictably. Both toxicity and loss of efficacy are possible.
What this interaction means in plain words
Erlotinib and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erlotinib belongs to Oncology; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol has mixed CYP3A4 inhibitory and inducing effects, as well as CYP1A2 effects, altering erlotinib metabolism.
What to do
Monitor for erlotinib toxicity and for loss of response, and adjust the dose according to tolerability and effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Erlotinib with Stiripentol?
MediHelp rates the interaction as moderate. Erlotinib and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol can both inhibit and induce CYP3A4, so erlotinib exposure may rise or fall unpredictably. Both toxicity and loss of efficacy are possible.
How serious is the interaction between Erlotinib and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erlotinib toxicity and for loss of response, and adjust the dose according to tolerability and effect.
What other medicines interact with Erlotinib?
MediHelp also lists interactions of Erlotinib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Erlotinib page.
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