Drug interactions
Erythromycin + Fedratinib
Severity: Moderate
Erythromycin and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4 and may raise erythromycin levels, adding to dose-related adverse effects such as QT prolongation. Erythromycin may also increase fedratinib exposure, raising the risk of gastrointestinal toxicity and encephalopathy.
What this interaction means in plain words
Erythromycin and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Fedratinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by fedratinib reduces erythromycin clearance, and erythromycin inhibits fedratinib metabolism.
What to do
Monitor for erythromycin toxicity and consider an ECG if QT risk factors exist. Reduce fedratinib dose per labeling when a moderate CYP3A4 inhibitor must be used, or select an alternative antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Erythromycin and Fedratinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Erythromycin with Fedratinib?
MediHelp rates the interaction as moderate. Erythromycin and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP3A4 and may raise erythromycin levels, adding to dose-related adverse effects such as QT prolongation. Erythromycin may also increase fedratinib exposure, raising the risk of gastrointestinal toxicity and encephalopathy.
How serious is the interaction between Erythromycin and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erythromycin toxicity and consider an ECG if QT risk factors exist. Reduce fedratinib dose per labeling when a moderate CYP3A4 inhibitor must be used, or select an alternative antibiotic.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
