Drug interactions
Erythromycin + Fexofenadine
Severity: Minor
Erythromycin and Fexofenadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin can raise fexofenadine exposure by roughly doubling its absorption and reducing its elimination. Because fexofenadine has a wide safety margin and little cardiac liability at usual doses, clinically important effects are uncommon.
What this interaction means in plain words
Erythromycin and Fexofenadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erythromycin belongs to Anti Bacterial; Fexofenadine belongs to Respiratory.
Why it happens
Erythromycin inhibits P-glycoprotein-mediated efflux of fexofenadine in the gut and elsewhere, and may also affect OATP transporters.
What to do
No dose adjustment is generally needed; counsel the patient to report excessive sedation or palpitations.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Frequently asked questions
Can I take Erythromycin with Fexofenadine?
MediHelp rates the interaction as minor. Erythromycin and Fexofenadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin can raise fexofenadine exposure by roughly doubling its absorption and reducing its elimination. Because fexofenadine has a wide safety margin and little cardiac liability at usual doses, clinically important effects are uncommon.
How serious is the interaction between Erythromycin and Fexofenadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; counsel the patient to report excessive sedation or palpitations.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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