Drug interactions
Erythromycin + Fostamatinib
Severity: Minor
Erythromycin and Fostamatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The active metabolite of fostamatinib inhibits P-glycoprotein and may increase erythromycin exposure. This could increase erythromycin adverse effects such as gastrointestinal upset and QT prolongation.
What this interaction means in plain words
Erythromycin and Fostamatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erythromycin belongs to Anti Bacterial; Fostamatinib belongs to Oncology.
Why it happens
P-glycoprotein inhibition by the fostamatinib metabolite tamatinib reduces erythromycin efflux.
What to do
Monitor for erythromycin adverse effects and reduce the dose if toxicity occurs. Consider an alternative antibiotic in patients with QT risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Erythromycin with Fostamatinib?
MediHelp rates the interaction as minor. Erythromycin and Fostamatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The active metabolite of fostamatinib inhibits P-glycoprotein and may increase erythromycin exposure. This could increase erythromycin adverse effects such as gastrointestinal upset and QT prolongation.
How serious is the interaction between Erythromycin and Fostamatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erythromycin adverse effects and reduce the dose if toxicity occurs. Consider an alternative antibiotic in patients with QT risk factors.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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