Drug interactions
Erythromycin + Goserelin
Severity: Moderate
Erythromycin and Goserelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy such as goserelin can prolong the QT interval, and combining it with erythromycin may increase the risk of torsades de pointes.
What this interaction means in plain words
Erythromycin and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Goserelin belongs to Endocrine.
Why it happens
Additive QT prolongation, with androgen deprivation affecting cardiac repolarization.
What to do
Check baseline ECG and electrolytes, and monitor QTc during erythromycin therapy; choose a non-QT-prolonging antibiotic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Goserelin
Frequently asked questions
Can I take Erythromycin with Goserelin?
MediHelp rates the interaction as moderate. Erythromycin and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy such as goserelin can prolong the QT interval, and combining it with erythromycin may increase the risk of torsades de pointes.
How serious is the interaction between Erythromycin and Goserelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes, and monitor QTc during erythromycin therapy; choose a non-QT-prolonging antibiotic in high-risk patients.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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