Drug interactions
Erythromycin + Levamlodipine
Severity: Moderate
Erythromycin and Levamlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin increases exposure to amlodipine-type calcium channel blockers by inhibiting CYP3A4. This can cause hypotension, peripheral edema and reflex tachycardia, particularly in older patients.
What this interaction means in plain words
Erythromycin and Levamlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Levamlodipine belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition by erythromycin reduces first-pass and systemic clearance of levamlodipine.
What to do
Monitor blood pressure and edema during and after the erythromycin course. Reduce the levamlodipine dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Levamlodipine
- Dantrolene + Levamlodipine Major
- Amiodarone + Levamlodipine Moderate
- Amobarbital + Levamlodipine Moderate
- Apalutamide + Levamlodipine Moderate
- Aprepitant + Levamlodipine Moderate
- Armodafinil + Levamlodipine Moderate
Frequently asked questions
Can I take Erythromycin with Levamlodipine?
MediHelp rates the interaction as moderate. Erythromycin and Levamlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin increases exposure to amlodipine-type calcium channel blockers by inhibiting CYP3A4. This can cause hypotension, peripheral edema and reflex tachycardia, particularly in older patients.
How serious is the interaction between Erythromycin and Levamlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema during and after the erythromycin course. Reduce the levamlodipine dose if hypotension occurs.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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