Drug interactions
Erythromycin + Omaveloxolone
Severity: Major
Erythromycin and Omaveloxolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin is a moderate CYP3A4 inhibitor and can raise omaveloxolone exposure, increasing the risk of adverse effects such as liver enzyme elevation and other dose-related toxicity. The effect is predictable from omaveloxolone's reliance on CYP3A4 metabolism.
What this interaction means in plain words
Erythromycin and Omaveloxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erythromycin belongs to Anti Bacterial; Omaveloxolone belongs to Central Nervous System.
Why it happens
Erythromycin inhibits CYP3A4-mediated metabolism of omaveloxolone, increasing its plasma concentrations.
What to do
Prefer a non-interacting antibiotic such as a non-macrolide alternative. If combined, reduce the omaveloxolone dose per labeling and monitor liver enzymes and tolerability.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Erythromycin with Omaveloxolone?
MediHelp rates the interaction as major. Erythromycin and Omaveloxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin is a moderate CYP3A4 inhibitor and can raise omaveloxolone exposure, increasing the risk of adverse effects such as liver enzyme elevation and other dose-related toxicity. The effect is predictable from omaveloxolone's reliance on CYP3A4 metabolism.
How serious is the interaction between Erythromycin and Omaveloxolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-interacting antibiotic such as a non-macrolide alternative. If combined, reduce the omaveloxolone dose per labeling and monitor liver enzymes and tolerability.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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