Drug interactions
Erythromycin + Ozanimod
Severity: Moderate
Erythromycin and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and conduction, and erythromycin prolongs the QT interval. Together they may heighten the risk of bradycardia-related arrhythmia, including torsades de pointes.
What this interaction means in plain words
Erythromycin and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Ozanimod belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects on cardiac conduction, with ozanimod causing bradycardia and erythromycin prolonging repolarization.
What to do
Obtain an ECG before starting ozanimod in patients taking erythromycin and seek cardiology advice if needed. Consider an alternative antibiotic such as a non-QT-prolonging agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Erythromycin with Ozanimod?
MediHelp rates the interaction as moderate. Erythromycin and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can slow heart rate and conduction, and erythromycin prolongs the QT interval. Together they may heighten the risk of bradycardia-related arrhythmia, including torsades de pointes.
How serious is the interaction between Erythromycin and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting ozanimod in patients taking erythromycin and seek cardiology advice if needed. Consider an alternative antibiotic such as a non-QT-prolonging agent.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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