Drug interactions
Erythromycin + Palbociclib
Severity: Moderate
Erythromycin and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may increase palbociclib exposure and the risk of neutropenia and other adverse effects. Strong CYP3A4 inhibitors have a well-documented effect, and moderate inhibitors like erythromycin may produce a smaller one.
What this interaction means in plain words
Erythromycin and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Palbociclib belongs to Oncology.
Why it happens
CYP3A4 inhibition by erythromycin decreases palbociclib clearance.
What to do
Monitor blood counts closely. Choose an alternative antibiotic if feasible, or reduce the palbociclib dose if neutropenia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Palbociclib
Frequently asked questions
Can I take Erythromycin with Palbociclib?
MediHelp rates the interaction as moderate. Erythromycin and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin may increase palbociclib exposure and the risk of neutropenia and other adverse effects. Strong CYP3A4 inhibitors have a well-documented effect, and moderate inhibitors like erythromycin may produce a smaller one.
How serious is the interaction between Erythromycin and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely. Choose an alternative antibiotic if feasible, or reduce the palbociclib dose if neutropenia develops.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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